Projects

Z: Central Projects

Dr. Dr. Melanie Börries
PD Dr. Silke Laßmann
PD Dr. rer. nat. Oliver Schilling

Systems biology, pathology and proteomics

Dr. med. Wilfried Reichardt
PD Dr. Dominik von Elverfeldt
Prof. Dr. Robert Zeiser

Imaging platform

Prof. Dr. med. Christoph Peters
Dr. rer. nat. Tim Lämmermann

Central Tasks of the Collaborative Research Center

Dr. Dr. Melanie Börries

Integrated Research Training Group on Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis

A: Control of Cell Movements in Development

Prof. Dr. rer. nat. Wolfgang Driever

Mechanisms controlling cell adhesion and motility in zebrafish stem cell proliferation zones

Prof. Dr. med. Sebastian Arnold
Dr. rer. nat. Tim Lämmermann

Advanced imaging of dynamic ECM-cell interactions using genetically encoded life-reporters during cell migration in development and in adult tissues

Prof. Dr. Ralf Baumeister

Non-cellautonomous role of the endoribonuclease ENDU-2/ENDOU/PP11 in tumorigenesis and invasion

Prof. Dr. med. Gerd Walz

Control of cell migration in response to injury by the cancer-associated adhesion molecule EpCAM

Dr. Anne-Kathrin Classen

Control of epithelial cell extrusion

C: Translation to Human Cancer and Novel Therapeutic Approaches

Prof. Dr. Gudula Schmidt

Minor splicing generates tumorigenic Rac variants in prostate cancer

PD Dr. Silke Laßmann

ErbB, Src and interactive signaling pathways in esophageal cancers

Prof. Dr. Robert Zeiser

miR-146a for cell migration in the tumor microenvironment

Dr. Dr. Melanie Börries
Dr. med. Ralph Fritsch

Integrated co-clinical analysis of 3-D tumor organoids to target invasion and metastasis in pancreatic cancer

Dr. rer. nat. Susana Minguet

Control of T cell motility by the biophysical properties of the tumor stroma

PD Dr. Rebecca Kesselring
Prof. Dr. med. Stefan Fichtner-Feigl

The role of local tumor barrier function for tumor cell plasticity, invasion and metastasis of colorectal cancer

B: Mechanisms of Tumor Cell Invasion and Metastasis

Prof. Dr. Roland Schüle

The novel arginine methyltransferase PRMT10 controls tumor growth and metastatic disease

Prof. Dr. rer. nat. Tilman Brummer

Understanding the role of the BRAFV600E oncoprotein in colorectal cancer initiation and metastasis

Prof. Dr. rer. nat. Andreas Hecht

Control of tumor cell proliferation, migration and invasion by SNAIL1-induced changes in Wnt and BMP pathway activity

Prof. Dr. med. Thomas Reinheckel
Prof. Dr. med. Christoph Peters

Therapeutic impact of protease deficiency on breast cancer invasion and metastasis

Prof. Dr. Marc Timmers

Epigenetic regulation of TGF- β/BMP and Snail-induced EMT signaling in colon cancer

Prof. Dr. Ian Frew

Epigenetic dysregulation in clear cell renal cell carcinoma metastasis

PhD Alexander Nyström
Dr. rer. nat. Tim Lämmermann

Cancer - microenvironment interactions in the progression to invasive squamous cell carcinoma

Get in contact

Coordinator
Prof. Dr. Christoph Peters
University of Freiburg

+49 (0)761 / 203 9600 christoph.peters@mol-med.uni-freiburg.de